DGCT (Database of Gastrointestinal Cancer Therapeutics)

An important advancement in the study of cancer is the establishment of a new database focused to gastrointestinal (GI) cancers. This database fills the knowledge gap by gathering useful biological data and thorough information on a variety of GI tumours. It helps researchers better understand the molecular pathways underlying tumour growth and spread by highlighting important hub genes that are involved in the initiation and advancement of certain malignancies.

The database has significant clinical implications in addition to its research applications. It provides professionals with a useful resource by providing a well selected list of drugs approved by the FDA currently used to treat gastrointestinal cancers. It also finds bioactive compounds from the CHEMBL database that share structural similarities with currently approved FDA medications. It might direct the creation of novel medications or their repurposing. By connecting molecular data with patient outcomes, the incorporation of survival analysis improves the database even further and offers a more comprehensive picture that supports both individualised treatment plans and more general cancer management initiatives. Important information required to develop this database were gathered from sources such as GeneCards, Cytoscape tool (version 3.10.3), STRING Database, RDKit and Kaplan Meier plotter.