Top Hub Genes	Chromosomal Location	Gene Ontology Information
KRAS	12p12.1	GTP binding and protein-containing complex binding
TP53	17p13.1	DNA-binding transcription factor activity and protein heterodimerization activity
EGFR	7p11.2	Identical protein binding and protein kinase activity
CDKN2A	9p21.3	RNA binding and transcription factor binding
AKT1	14q32.33	Identical protein binding and protein kinase activity
PIK3CA	3q26.32	Transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity
SMAD4	18q21.2	DNA-binding transcription factor activity and sequence-specific DNA binding
CEACAM5	19q13.2	Protein homodimerization activity and GPI anchor binding
MLH1	3p22.2	ATP Hydrolysis activity and mismatched DNA binding
KRT7	12q13.13	Structural molecule activity